Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice
Joint Authors
Mitome-Mishima, Yumiko
Urabe, Takao
Hattori, Nobutaka
Tanaka, Ryota
Shimosawa, Tatsuo
Miyamoto, Nobukazu
Arai, Hajime
Oishi, Hidenori
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Adrenomedullin was originally isolated from pheochromocytoma cells and reduces insulin resistance by decreasing oxidative stress.
White matter lesions induced by aging and hyperglycemia play a crucial role in cognitive impairment in poststroke patients.
Here, we examine whether adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion.
Adrenomedullin heterozygous, wild-type young/aged mice were subjected to prolonged hypoperfusion.
Prolonged cerebral hypoperfusion followed by immunohistochemical analysis was used to evaluate white matter injury.
After prolonged hypoperfusion, white matter damage progressed in a time-dependent manner in AM+/− group compared with the wild-type group.
The number of oligodendrocyte progenitor cells gradually increased after prolonged hypoperfusion, whereas oligodendrocytes decreased following a transient increase, but the ratio of increase was mild in the AM+/− group (P<0.05).
Oxidative stress was detected in oligodendrocytes, with a larger increase in the AM+/− group (P<0.05).
Aged mice showed the same tendency, but white matter damage was worse, especially in the aged AM+/− group.
Our results demonstrated that white matter injury was increased in adrenomedullin deficiency, which induced oxidative stress.
White matter injury was more exacerbated because of hyperglycemia in aged AM+/− group.
Adrenomedullin may be an important target in the control of ischemic white matter injury.
American Psychological Association (APA)
Mitome-Mishima, Yumiko& Miyamoto, Nobukazu& Tanaka, Ryota& Shimosawa, Tatsuo& Oishi, Hidenori& Arai, Hajime…[et al.]. 2014. Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-504198
Modern Language Association (MLA)
Mitome-Mishima, Yumiko…[et al.]. Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-504198
American Medical Association (AMA)
Mitome-Mishima, Yumiko& Miyamoto, Nobukazu& Tanaka, Ryota& Shimosawa, Tatsuo& Oishi, Hidenori& Arai, Hajime…[et al.]. Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-504198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504198