Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression : Antiplatelet Activity of Natural Products
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Platelets are no longer considered simply as cells participating in thrombosis.
In atherosclerosis, platelets are regulators of multiple processes, with the recruitment of inflammatory cells towards the lesion sites, inflammatory mediators release, and regulation of endothelial function.
The antiplatelet therapy has been used for a long time in an effort to prevent and treat cardiovascular diseases.
However, limited efficacy in some patients, drug resistance, and side effects are limitations of current antiplatelet therapy.
In this context, a large number of natural products (polyphenols, terpenoids, alkaloids, and fatty acids) have been reported with antiplatelet activity.
In this sense, the present paper describes mechanisms of antiplatelet action of natural products on platelet P-selectin expression through cAMP levels and its role as peroxisome proliferator-activated receptors agonists.
American Psychological Association (APA)
Fuentes, Eduardo& Palomo, Iván. 2013. Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression : Antiplatelet Activity of Natural Products. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504214
Modern Language Association (MLA)
Fuentes, Eduardo& Palomo, Iván. Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression : Antiplatelet Activity of Natural Products. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-504214
American Medical Association (AMA)
Fuentes, Eduardo& Palomo, Iván. Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression : Antiplatelet Activity of Natural Products. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504214