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Use of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients
Joint Authors
Victor, Brett
Karalis, Dean G.
Liu, Longjian
Ahedor, Lilian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
In clinical practice, most coronary artery disease patients are not achieving their recommend LDL-cholesterol goal of <70 mg/dL.
Methods.
We conducted a retrospective analysis of outpatient electronic health records and the most recent lipid profile, lipid-lowering medications and doses were collected.
Results.
We identified 9950 coronary artery disease patients.
Only 37% on a statin alone achieved an LDL-cholesterol of <70 mg/dL, and most were on moderate-to-high-potency statins.
The intensity of statin therapy did not improve LDL-cholesterol goal attainment.
Among patients on combination therapy, 41% on statin plus ezetimibe and 46% on statin plus niacin achieved an LDL-cholesterol of <70 mg/dL (P=0.01 and <0.0001 versus statin alone).
If patients were switched to a high-potency statin LDL-cholesterol goal attainment of <70 mg/dL would increase to 46% and would increase up to 72% with combination therapy.
Conclusions.
Most coronary artery disease patients in clinical practice do not attain an LDL-cholesterol of <70 mg/dL, even among patients on high potency statins.
The combination of statin plus either ezetimibe or niacin is the most effective regimen to achieve an LDL-cholesterol of <70 mg/dL, however, these drug combinations are used infrequently in clinical practice.
American Psychological Association (APA)
Karalis, Dean G.& Victor, Brett& Ahedor, Lilian& Liu, Longjian. 2012. Use of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients. Cholesterol،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-504234
Modern Language Association (MLA)
Karalis, Dean G.…[et al.]. Use of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients. Cholesterol No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-504234
American Medical Association (AMA)
Karalis, Dean G.& Victor, Brett& Ahedor, Lilian& Liu, Longjian. Use of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients. Cholesterol. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-504234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504234