5-ALA Mediated Fluorescence Detection of Gastrointestinal Tumors
Joint Authors
Borisova, Ekaterina
Vladimirov, Borislav
Avramov, Latchezar
Source
Advances in Optical Technologies
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-08-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
Delta-aminolevulinic acid/protoporphyrin IX is applied for fluorescent tumor detection in the upper part of gastrointestinal tract.
The 5-ALA is administered per os six hours before measurements at dose 20 mg/kg weight.
High-power light-emitting diode at 405 nm is used as an excitation source.
Special opto-mechanical device is built to use the light guide of standard video-endoscopic system.
Through endoscopic instrumental channel a fiber is applied to return information about fluorescence to microspectrometer.
In such way, 1D detection and 2D visualization of the lesions' fluorescence are received, and both advantages and limitations of these methodologies are discussed in relation to their clinical applicability.
Comparison of the spectra received from normal mucosa, inflammatory, and tumor areas is applied to evaluate the feasibility for development of simple but effective algorithm based on dimensionless ratio of the fluorescence signals at 560 and 635 nm, for differentiation of normal/abnormal gastrointestinal tissues.
American Psychological Association (APA)
Borisova, Ekaterina& Vladimirov, Borislav& Avramov, Latchezar. 2008. 5-ALA Mediated Fluorescence Detection of Gastrointestinal Tumors. Advances in Optical Technologies،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-504249
Modern Language Association (MLA)
Borisova, Ekaterina…[et al.]. 5-ALA Mediated Fluorescence Detection of Gastrointestinal Tumors. Advances in Optical Technologies No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-504249
American Medical Association (AMA)
Borisova, Ekaterina& Vladimirov, Borislav& Avramov, Latchezar. 5-ALA Mediated Fluorescence Detection of Gastrointestinal Tumors. Advances in Optical Technologies. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-504249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504249