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Beneficial Effect of the Traditional Chinese Drug Shu-Xue-Tong on Recovery of Spinal Cord Injury in the Rat
Joint Authors
Kuang, Fang
Shen, Xue-Feng
Jia, Li-Yun
Yao, An-Hui
Ju, Gong
Zhang, Yu-Kai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Shu-Xue-Tong (SXT) is a traditional Chinese drug widely used to ameliorate stagnation of blood flow, such as brain or myocardial infarction.
Whether SXT may have therapeutic value for spinal cord injury (SCI), during which ischemia plays an important role in its pathology, remains to be elucidated.
We hypothesized that SXT may promote SCI healing by improving spinal cord blood flow (SCBF), and a study was thus designed to explore this possibility.
Twenty-five male Sprague-Dawley rats were used.
SCI was induced by compression, and SXT was administrated 24 h postinjury for 14 successive days.
The effects of SXT were assessed by means of laser-Doppler flowmetry, motor functional analysis (open-field walking and footprint analysis), and histological analysis (hematoxylin-eosin and thionin staining and NeuN immunohistochemistry).
SXT significantly promoted SCBF of the contused spinal cord and enhanced the recovery of motor function.
Histological analysis indicated that the lesion size was reduced, the pathological changes were ameliorated, and more neurons were preserved.
Based on these results we conclude that SXT can effectively improve SCI.
American Psychological Association (APA)
Jia, Li-Yun& Yao, An-Hui& Kuang, Fang& Zhang, Yu-Kai& Shen, Xue-Feng& Ju, Gong. 2010. Beneficial Effect of the Traditional Chinese Drug Shu-Xue-Tong on Recovery of Spinal Cord Injury in the Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504262
Modern Language Association (MLA)
Jia, Li-Yun…[et al.]. Beneficial Effect of the Traditional Chinese Drug Shu-Xue-Tong on Recovery of Spinal Cord Injury in the Rat. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-504262
American Medical Association (AMA)
Jia, Li-Yun& Yao, An-Hui& Kuang, Fang& Zhang, Yu-Kai& Shen, Xue-Feng& Ju, Gong. Beneficial Effect of the Traditional Chinese Drug Shu-Xue-Tong on Recovery of Spinal Cord Injury in the Rat. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504262