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Reactive Oxygen Species and the Cardiovascular System
Joint Authors
Merkus, Daphne
Taverne, Yannick J. H. J.
Bogers, Ad J. J. C.
Duncker, Dirk J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Ever since the discovery of free radicals, many hypotheses on the deleterious actions of reactive oxygen species (ROS) have been proposed.
However, increasing evidence advocates the necessity of ROS for cellular homeostasis.
ROS are generated as inherent by-products of aerobic metabolism and are tightly controlled by antioxidants.
Conversely, when produced in excess or when antioxidants are depleted, ROS can inflict damage to lipids, proteins, and DNA.
Such a state of oxidative stress is associated with many pathological conditions and closely correlated to oxygen consumption.
Although the deleterious effects of ROS can potentially be reduced by restoring the imbalance between production and clearance of ROS through administration of antioxidants (AOs), the dosage and type of AOs should be tailored to the location and nature of oxidative stress.
This paper describes several pathways of ROS signaling in cellular homeostasis.
Further, we review the function of ROS in cardiovascular pathology and the effects of AOs on cardiovascular outcomes with emphasis on the so-called oxidative paradox.
American Psychological Association (APA)
Taverne, Yannick J. H. J.& Bogers, Ad J. J. C.& Duncker, Dirk J.& Merkus, Daphne. 2013. Reactive Oxygen Species and the Cardiovascular System. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-504272
Modern Language Association (MLA)
Taverne, Yannick J. H. J.…[et al.]. Reactive Oxygen Species and the Cardiovascular System. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-504272
American Medical Association (AMA)
Taverne, Yannick J. H. J.& Bogers, Ad J. J. C.& Duncker, Dirk J.& Merkus, Daphne. Reactive Oxygen Species and the Cardiovascular System. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-504272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504272