Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Salicylic Acid as Antimycobacterial Agents
Joint Authors
Faidallah, Hassan M.
Khan, Khalid Ali
Makki, Mohammed Saleh I. T.
Abdel-Rahman, Reda M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A series of new N,N′-substituted thioureas (2, 6, and 8) and their sulfur heterocycles as thiobarbituric acids (3, 4, and 7), 2-thioxothiazoliodin-4-one (10), thiazolidin-4-one (11), 1,2,4-triazol-5-thione (14), and 1,3,4-thiadiazole (15) of p-Amino salicylic acid (PAS) have been synthesized from treatment with dithiocarbazinate (1, 5 and 12) followed by heterocyclization with dimethyl malonate, chloroacetic acid, and/or trifluoroacetic anhydride.
The structures of the newly synthesized compounds were substantiated with IR, H1, and C13 NMR spectral data and elementary microanalyses.
The in vitro antitubercular activity of synthesized compounds against M.
tuberculosis strain H37Rv showed moderate-to-good activity.
American Psychological Association (APA)
Makki, Mohammed Saleh I. T.& Abdel-Rahman, Reda M.& Faidallah, Hassan M.& Khan, Khalid Ali. 2012. Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Salicylic Acid as Antimycobacterial Agents. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504273
Modern Language Association (MLA)
Makki, Mohammed Saleh I. T.…[et al.]. Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Salicylic Acid as Antimycobacterial Agents. Journal of Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-504273
American Medical Association (AMA)
Makki, Mohammed Saleh I. T.& Abdel-Rahman, Reda M.& Faidallah, Hassan M.& Khan, Khalid Ali. Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Salicylic Acid as Antimycobacterial Agents. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504273