Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients
Joint Authors
Høstmark, Arne Torbjørn
Fausa, O.
Almendingen, K.
Aabakken, Lars
Larsen, L. N.
Bratlie, J.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A few familial adenomatous polyposis studies have focused upon faecal sterols and bile acids but none has analysed the fecal content of fatty acids.
We report here findings of an observational study on 29 colectomized familial adenomatous polyposis patients that describe the fecal content of fatty acids, and relate this to the proportions of fatty acids and levels of cyclooxygenase mRNA expression in duodenal biopsies, levels of serum lipoproteins, and diet.
In the ileostomy group separately (n=12), the fecal content of arachidonic acid was correlated negatively to the proportions of eicosapentaenoic acid and docosahexaenoic acid in duodenal biopsies.
Total serum-cholesterol was negatively correlated to the fecal content of saturates and monounsaturates.
The fecal palmitoleic acid/palmitic acid ratio was positively correlated to the levels of cyclooxygease-2 expression in duodenal biopsies.In the ileal-pouch-anal anastomosis group separately (n=17), significant correlations were found between the fecal contents of oleic acid, linoleic acid, and alpha-linolenic acid, and the proportions of myristic acid, oleic acid and eicosaenoic acid in duodenal biopsies.
Dietary monounsaturates were positively correlated to different fecal fatty acids.
Future studies should focus on molecular mechanisms relevant to fatty acid metabolism, inflammation, and angiogenesis, in addition to nutrition.
American Psychological Association (APA)
Almendingen, K.& Høstmark, Arne Torbjørn& Larsen, L. N.& Fausa, O.& Bratlie, J.& Aabakken, Lars. 2010. Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients. Journal of Nutrition and Metabolism،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504294
Modern Language Association (MLA)
Almendingen, K.…[et al.]. Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients. Journal of Nutrition and Metabolism No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-504294
American Medical Association (AMA)
Almendingen, K.& Høstmark, Arne Torbjørn& Larsen, L. N.& Fausa, O.& Bratlie, J.& Aabakken, Lars. Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients. Journal of Nutrition and Metabolism. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504294