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Enhanced Muscle Growth by Plasmid-Mediated Delivery of Myostatin Propeptide
Joint Authors
Qiao, Jun
Sheng, Jingliang
Chen, Chuangfu
Hu, Shengwei
Sun, Yufang
Cao, Xudong
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Myostatin is a member of the transforming growth factor beta (TGF-β) superfamily that functions as a negative regulator of skeletal muscle development and growth.
Myostatin blockade therefore offers a strategy for promoting muscle growth in livestock production without resorting to genetic manipulation.
In this report, we examined the effect of myostatin inhibition by plasmid-mediated delivery of a mutant myostatin propeptide (MProD76A), a natural inhibitor of myostatin, on the growth performance of mice.
A significant increase in skeletal muscle mass was observed after a single intramuscular injection of naked plasmid DNA encoding MProD76A into mice.
Enhanced muscle growth occurred because of myofiber hypertrophy, but no cardiac muscle hypertrophy and organomegaly was observed in the mice after myostatin inhibition by plasmid-mediated MProD76A delivery.
These results demonstrate a promising approach to enhancing muscle growth that warrants further investigation in domestic animals.
American Psychological Association (APA)
Hu, Shengwei& Chen, Chuangfu& Sheng, Jingliang& Sun, Yufang& Cao, Xudong& Qiao, Jun. 2010. Enhanced Muscle Growth by Plasmid-Mediated Delivery of Myostatin Propeptide. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-504297
Modern Language Association (MLA)
Hu, Shengwei…[et al.]. Enhanced Muscle Growth by Plasmid-Mediated Delivery of Myostatin Propeptide. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-504297
American Medical Association (AMA)
Hu, Shengwei& Chen, Chuangfu& Sheng, Jingliang& Sun, Yufang& Cao, Xudong& Qiao, Jun. Enhanced Muscle Growth by Plasmid-Mediated Delivery of Myostatin Propeptide. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-504297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504297