Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4 via PI3KAkt Pathway in LPS-Induced Acute Lung Injury
Joint Authors
Yang, Li
Cheng, Yang
Lian, Qing-Quan
Jin, Sheng-Wei
Yang, Yi
Qi, Wei
Liu, Yong-Jian
Wu, De-Rong
Smith, Fang Gao
Li, Wen-Juan
Zheng, Xia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The lipoxins are the first proresolution mediators to be recognized and described as the endogenous “braking signals” for inflammation.
We evaluated the anti-inflammatory and proresolution bioactions of lipoxin A4 in our lipopolysaccharide (LPS-)induced lung injury model.
We demonstrated that lipoxin A4 significantly improved histology of rat lungs and inhibited IL-6 and TNF-α in LPS-induced lung injury.
In addition, lipoxin A4 increased alveolar fluid clearance (AFC) and the effect of lipoxin A4 on AFC was abolished by CFTRinh-172 (a specific inhibitor of CFTR).
Moreover, lipoxin A4 could increase cystic fibrosis transmembrane conductance regulator (CFTR) protein expression in vitro and in vivo.
In rat primary alveolar type II (ATII) cells, LPS decreased CFTR protein expression via activation of PI3K/Akt, and lipoxin A4 suppressed LPS-stimulated phosphorylation of Akt.
These results showed that lipoxin A4 enhanced CFTR protein expression and increased AFC via PI3K/Akt pathway.
Thus, lipoxin A4 may provide a potential therapeutic approach for acute lung injury.
American Psychological Association (APA)
Yang, Yi& Cheng, Yang& Lian, Qing-Quan& Yang, Li& Qi, Wei& Wu, De-Rong…[et al.]. 2013. Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4 via PI3KAkt Pathway in LPS-Induced Acute Lung Injury. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504302
Modern Language Association (MLA)
Yang, Yi…[et al.]. Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4 via PI3KAkt Pathway in LPS-Induced Acute Lung Injury. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-504302
American Medical Association (AMA)
Yang, Yi& Cheng, Yang& Lian, Qing-Quan& Yang, Li& Qi, Wei& Wu, De-Rong…[et al.]. Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4 via PI3KAkt Pathway in LPS-Induced Acute Lung Injury. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504302