Rapid Recovery from Chronic PRCA by MSC Infusion in Patient after Major ABO-Mismatched alloSCT
Joint Authors
Sergeevicheva, Vera
Chernykh, Elena R.
Kulagin, Alexander
Lisukov, Igor
L'vovich, Gelfgat Evgenii
Gilevich, Andrey
Kruchkova, Irina
Sergeevichev, David
Shevela, Ekaterina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Pure red cell aplasia (PRCA) is a rare complication in recipients of allogenic stem cell from ABO incompatible donors.
It is characterized by reticulocytopenia and by an absence of red cell cell precursors in the bone marrow.
Despite close isohemagglutinins monitoring and standard immunosupressive treatment in these patients prolong PRCA are still associated with severe transfusion dependence.
We report the case of a 31 yr old male patient who underwent HLA-matched ABO-mismatched allo-SCT and developed resistance PRCA despite conventional immunosupressive therapy and prophylaxis cotrasplantation of bone marrow derived MSC at day 0.
He responded dramatically to therapy with adipose tissue derived mesenchymal stem cells from HSC donors and continued to be transfusion-independent and AML-disease free.
This method of the PRCA therapy of deserves further investigation.
American Psychological Association (APA)
Sergeevicheva, Vera& Kruchkova, Irina& Chernykh, Elena R.& Shevela, Ekaterina& Kulagin, Alexander& Gilevich, Andrey…[et al.]. 2012. Rapid Recovery from Chronic PRCA by MSC Infusion in Patient after Major ABO-Mismatched alloSCT. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-504310
Modern Language Association (MLA)
Sergeevicheva, Vera…[et al.]. Rapid Recovery from Chronic PRCA by MSC Infusion in Patient after Major ABO-Mismatched alloSCT. Case Reports in Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-504310
American Medical Association (AMA)
Sergeevicheva, Vera& Kruchkova, Irina& Chernykh, Elena R.& Shevela, Ekaterina& Kulagin, Alexander& Gilevich, Andrey…[et al.]. Rapid Recovery from Chronic PRCA by MSC Infusion in Patient after Major ABO-Mismatched alloSCT. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-504310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504310