![](/images/graphics-bg.png)
Efficacy and Cost-Efficacy of Biologic Therapies for Moderate to Severe Psoriasis : A Meta-Analysis and Cost-Efficacy Analysis Using the Intention-to-Treat Principle
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Compared to conventional therapies, biologics are more effective but expensive in treating psoriasis.
Objective.
To evaluate the efficacy and cost-efficacy of biologic therapies for psoriasis.
Methods.
We conducted a meta-analysis to calculate the efficacy of etanercept, adalimumab, infliximab, and ustekinumab for at least 75% reduction in the Psoriasis Area and Severity Index score (PASI 75) and Physician’s Global Assessment clear/minimal (PGA 0/1).
The cost-efficacy was assessed by calculating the incremental cost-effectiveness ratio (ICER) per subject achieving PASI 75 and PGA 0/1.
Results.
The incremental efficacy regarding PASI 75 was 55% (95% confidence interval (95% CI) 38%–72%), 63% (95% CI 59%–67%), 71% (95% CI 67%–76%), 67% (95% CI 62%–73%), and 72% (95% CI 68%–75%) for etanercept, adalimumab, infliximab, and ustekinumab 45 mg and 90 mg, respectively.
The corresponding 6-month ICER regarding PASI 75 was $32,643 (best case $24,936; worst case $47,246), $21,315 (best case $20,043; worst case $22,760), $27,782 (best case $25,954; worst case $29,440), $25,055 (best case $22,996; worst case $27,075), and $46,630 (best case $44,765; worst case $49,373), respectively.
The results regarding PGA 0/1 were similar.
Conclusions.
Infliximab and ustekinumab 90 mg had the highest efficacy.
Meanwhile, adalimumab had the best cost-efficacy, followed by ustekinumab 45 mg and infliximab.
American Psychological Association (APA)
Chi, Ching-Chi& Wang, Shu-Hui. 2014. Efficacy and Cost-Efficacy of Biologic Therapies for Moderate to Severe Psoriasis : A Meta-Analysis and Cost-Efficacy Analysis Using the Intention-to-Treat Principle. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-504320
Modern Language Association (MLA)
Chi, Ching-Chi& Wang, Shu-Hui. Efficacy and Cost-Efficacy of Biologic Therapies for Moderate to Severe Psoriasis : A Meta-Analysis and Cost-Efficacy Analysis Using the Intention-to-Treat Principle. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-504320
American Medical Association (AMA)
Chi, Ching-Chi& Wang, Shu-Hui. Efficacy and Cost-Efficacy of Biologic Therapies for Moderate to Severe Psoriasis : A Meta-Analysis and Cost-Efficacy Analysis Using the Intention-to-Treat Principle. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-504320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504320