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Weekly Paclitaxel plus Capecitabine versus Docetaxel Every 3 Weeks plus Capecitabine in Metastatic Breast Cancer
Joint Authors
Sommer, H. H.
Løkkevik, Erik
Wist, E. A.
Mjaaland, I.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
We performed a randomized phase II study comparing efficacy and toxicity of weekly paclitaxel 80 mg/m2 (Weetax) with three weekly docetaxel 75 mg/m2 (Threetax), both in combination with oral capecitabine 1000 mg/m2 twice daily for 2 weeks followed by a 1-week break.
Patients.
Thirty-seven women with confirmed metastatic breast cancer were randomized.
Results.
Median TTF was 174 (Weetax) versus 147 days (Threetax) (P=0.472).
Median OS was 933 (Weetax) versus 464 days (Threetax) (P=0.191).
Reasons for TTF were PD 8/18 (Weetax), 9/19 (Threetax); and toxicity: 8/18 (Weetax), 8/19 (Threetax).
ORR was 72% (Weetax) versus 26% (Threetax) (P=0.01).
The Threetax-combination resulted in a higher incidence of leuco-/neutropenia compared to Weetax.
Grade II anemia was more pronounced in the Weetax group.
No difference was found in quality of life.
Conclusion.
Taxanes in combination with capecitabine resulted in a high level of toxicity.
Taxanes and capecitabine should be considered given sequentially and not in combination.
American Psychological Association (APA)
Wist, E. A.& Mjaaland, I.& Løkkevik, Erik& Sommer, H. H.. 2012. Weekly Paclitaxel plus Capecitabine versus Docetaxel Every 3 Weeks plus Capecitabine in Metastatic Breast Cancer. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-504328
Modern Language Association (MLA)
Wist, E. A.…[et al.]. Weekly Paclitaxel plus Capecitabine versus Docetaxel Every 3 Weeks plus Capecitabine in Metastatic Breast Cancer. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-504328
American Medical Association (AMA)
Wist, E. A.& Mjaaland, I.& Løkkevik, Erik& Sommer, H. H.. Weekly Paclitaxel plus Capecitabine versus Docetaxel Every 3 Weeks plus Capecitabine in Metastatic Breast Cancer. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-504328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504328