Tolerance Induction Strategies in Vascularized Composite Allotransplantation : Mixed Chimerism and Novel Developments
Joint Authors
Cetrulo, Curtis L.
Kurtz, Josef M.
Leonard, David A.
McGrouther, Duncan A.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Since the start of the clinical vascularized composite allotransplantation (VCA) era over a decade ago this field has witnessed significant developments in both basic and translational research.
Transplant tolerance, defined as rejection-free acceptance of transplanted organs or tissues without long-term immunosuppression, holds the potential to revolutionize the field of VCA by removing the need for life-long immunosuppression.
While tolerance of organ and vascularized composite transplants may be induced in small animal models by a variety of protocols, only mixed-chimerism-based protocols have successfully bridged the gap to preclinical study and to clinical trial in solid organ transplantation to date.
In this paper we review the mixed-chimerism approach to tolerance induction, with specific reference to the field of VCA transplantation, and provide an overview of some novel cellular therapies as potential adjuvants to mixed chimerism in the development of tolerance induction protocols for clinical vascularized composite allotransplantation.
American Psychological Association (APA)
Leonard, David A.& McGrouther, Duncan A.& Kurtz, Josef M.& Cetrulo, Curtis L.. 2012. Tolerance Induction Strategies in Vascularized Composite Allotransplantation : Mixed Chimerism and Novel Developments. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-504370
Modern Language Association (MLA)
Leonard, David A.…[et al.]. Tolerance Induction Strategies in Vascularized Composite Allotransplantation : Mixed Chimerism and Novel Developments. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-504370
American Medical Association (AMA)
Leonard, David A.& McGrouther, Duncan A.& Kurtz, Josef M.& Cetrulo, Curtis L.. Tolerance Induction Strategies in Vascularized Composite Allotransplantation : Mixed Chimerism and Novel Developments. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-504370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504370