Mechanotransduction in Musculoskeletal Tissue Regeneration : Effects of Fluid Flow, Loading, and Cellular-Molecular Pathways
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
While mechanotransductive signal is proven essential for tissue regeneration, it is critical to determine specific cellular responses to such mechanical signals and the underlying mechanism.
Dynamic fluid flow induced by mechanical loading has been shown to have the potential to regulate bone adaptation and mitigate bone loss.
Mechanotransduction pathways are of great interests in elucidating how mechanical signals produce such observed effects, including reduced bone loss, increased bone formation, and osteogenic cell differentiation.
The objective of this review is to develop a molecular understanding of the mechanotransduction processes in tissue regeneration, which may provide new insights into bone physiology.
We discussed the potential for mechanical loading to induce dynamic bone fluid flow, regulation of bone adaptation, and optimization of stimulation parameters in various loading regimens.
The potential for mechanical loading to regulate microcirculation is also discussed.
Particularly, attention is allotted to the potential cellular and molecular pathways in response to loading, including osteocytes associated with Wnt signaling, elevation of marrow stem cells, and suppression of adipotic cells, as well as the roles of LRP5 and microRNA.
These data and discussions highlight the complex yet highly coordinated process of mechanotransduction in bone tissue regeneration.
American Psychological Association (APA)
Qin, Yi-Xian& Hu, Minyi. 2014. Mechanotransduction in Musculoskeletal Tissue Regeneration : Effects of Fluid Flow, Loading, and Cellular-Molecular Pathways. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-504380
Modern Language Association (MLA)
Qin, Yi-Xian& Hu, Minyi. Mechanotransduction in Musculoskeletal Tissue Regeneration : Effects of Fluid Flow, Loading, and Cellular-Molecular Pathways. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-504380
American Medical Association (AMA)
Qin, Yi-Xian& Hu, Minyi. Mechanotransduction in Musculoskeletal Tissue Regeneration : Effects of Fluid Flow, Loading, and Cellular-Molecular Pathways. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-504380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504380