The Function of CD3+CD56+ NKT-Like Cells in HIV-Infected Individuals
Joint Authors
Fu, Yajing
Xu, Jun-Jie
Liao, Christina
Chu, Zhen-Xing
Cui, Xiaojian
Cui, Chen
Wang, Yanan
Shang, Hong
Zhang, Jian
Zhang, Zining
Zhou, Fangyuan
Han, Xiaoxu
Liu, Jing
Cao, Yaming
Jiang, Yong-Jun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CD3+CD56+ NKT-like cells are one of the critical effectors in the immune response to viral infection and tumors, but the functional features of NKT-like cells in HIV infection have been rarely reported.
In this study, we observed and described the state of NKT-like cell functions in primary HIV-infected individuals (PHIs), chronic HIV-infected individuals (CHIs), long-term nonprogressors (LTNPs), and HIV-negative controls (NCs).
The results showed that the percentage of IFN-γ+CD3+CD56+ NKT-like cells was notably higher in LTNPs compared with CHIs, and the proportion of CD3+CD56+ NKT-like cells with dual function (IFN-γ+CD107a+ NKT-like cells) in LTNPs was also much higher than in CHIs.
Additionally, the percentages of IFN-γ+CD107a+ NKT-like cells negatively correlated with viral load.
Taken together, our data demonstrated that good functions of CD3+CD56+ NKT-like cells in LTNPs likely occurred as a protective mechanism that slows down HIV disease progression.
American Psychological Association (APA)
Jiang, Yong-Jun& Cui, Xiaojian& Cui, Chen& Zhang, Jian& Zhou, Fangyuan& Zhang, Zining…[et al.]. 2014. The Function of CD3+CD56+ NKT-Like Cells in HIV-Infected Individuals. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-504407
Modern Language Association (MLA)
Jiang, Yong-Jun…[et al.]. The Function of CD3+CD56+ NKT-Like Cells in HIV-Infected Individuals. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-504407
American Medical Association (AMA)
Jiang, Yong-Jun& Cui, Xiaojian& Cui, Chen& Zhang, Jian& Zhou, Fangyuan& Zhang, Zining…[et al.]. The Function of CD3+CD56+ NKT-Like Cells in HIV-Infected Individuals. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-504407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504407
