Metabolic and Cardiovascular Effects of Ghrelin
Joint Authors
Schinzari, Francesca
Lauro, Renato
Tesauro, Manfredi
Cardillo, Carmine
Caramanti, Miriam
Source
International Journal of Peptides
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized as a preprohormone and then proteolytically processed to yield a 28-amino acid peptide.
This peptide was originally reported to induce growth hormone release; large evidence, however, has indicated many other physiological activities of ghrelin, including regulation of food intake and energy balance, as well as of lipid and glucose metabolism.
Ghrelin receptors have been detected in the hypothalamus and the pituitary, but also in the cardiovascular system, where ghrelin exerts beneficial hemodynamic activities.
Ghrelin administration acutely improves endothelial dysfunction by increasing nitric oxide bioavailability and normalizes the altered balance between endothelin-1 and nitric oxide within the vasculature of patients with metabolic syndrome.
Other cardiovascular effects of ghrelin include improvement of left ventricular contractility and cardiac output, as well as reduction of arterial pressure and systemic vascular resistance.
In addition, antinflammatory and antiapoptotic actions of ghrelin have been reported both in vivo and in vitro.
This review summarizes the most recent findings on the metabolic and cardiovascular effects of ghrelin through GH-dependent and -independent mechanisms and the possible role of ghrelin as a therapeutic molecule for treating cardiovascular diseases.
American Psychological Association (APA)
Tesauro, Manfredi& Schinzari, Francesca& Caramanti, Miriam& Lauro, Renato& Cardillo, Carmine. 2010. Metabolic and Cardiovascular Effects of Ghrelin. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504478
Modern Language Association (MLA)
Tesauro, Manfredi…[et al.]. Metabolic and Cardiovascular Effects of Ghrelin. International Journal of Peptides No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-504478
American Medical Association (AMA)
Tesauro, Manfredi& Schinzari, Francesca& Caramanti, Miriam& Lauro, Renato& Cardillo, Carmine. Metabolic and Cardiovascular Effects of Ghrelin. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504478