Metabolic and Cardiovascular Effects of Ghrelin

Joint Authors

Schinzari, Francesca
Lauro, Renato
Tesauro, Manfredi
Cardillo, Carmine
Caramanti, Miriam

Source

International Journal of Peptides

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-03-16

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Chemistry

Abstract EN

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized as a preprohormone and then proteolytically processed to yield a 28-amino acid peptide.

This peptide was originally reported to induce growth hormone release; large evidence, however, has indicated many other physiological activities of ghrelin, including regulation of food intake and energy balance, as well as of lipid and glucose metabolism.

Ghrelin receptors have been detected in the hypothalamus and the pituitary, but also in the cardiovascular system, where ghrelin exerts beneficial hemodynamic activities.

Ghrelin administration acutely improves endothelial dysfunction by increasing nitric oxide bioavailability and normalizes the altered balance between endothelin-1 and nitric oxide within the vasculature of patients with metabolic syndrome.

Other cardiovascular effects of ghrelin include improvement of left ventricular contractility and cardiac output, as well as reduction of arterial pressure and systemic vascular resistance.

In addition, antinflammatory and antiapoptotic actions of ghrelin have been reported both in vivo and in vitro.

This review summarizes the most recent findings on the metabolic and cardiovascular effects of ghrelin through GH-dependent and -independent mechanisms and the possible role of ghrelin as a therapeutic molecule for treating cardiovascular diseases.

American Psychological Association (APA)

Tesauro, Manfredi& Schinzari, Francesca& Caramanti, Miriam& Lauro, Renato& Cardillo, Carmine. 2010. Metabolic and Cardiovascular Effects of Ghrelin. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504478

Modern Language Association (MLA)

Tesauro, Manfredi…[et al.]. Metabolic and Cardiovascular Effects of Ghrelin. International Journal of Peptides No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-504478

American Medical Association (AMA)

Tesauro, Manfredi& Schinzari, Francesca& Caramanti, Miriam& Lauro, Renato& Cardillo, Carmine. Metabolic and Cardiovascular Effects of Ghrelin. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504478

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-504478