Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma
Joint Authors
Duan, Yuxiu
Song, Xinwen
Wang, Hongwei
Gao, Haili
Li, Aihui
Hou, Lijuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
New strategies for the diagnosis of hepatocellular carcinoma (HCC) are urgently needed.
There is an increasing interest in using microRNAs (miRNAs) as biomarkers in diseases.
In this study, we examined the expression of miR-21 in serum exosomes from patients with HCC or chronic hepatitis B (CHB) and investigated the potential clinical significance of miR-21.
Quantitative RT-PCR indicated that the concentration of miR-21 was significantly higher in exosomes than in exosome-depleted supernatants or the whole serum.
Further, the expression level of serum exosomal miR-21 was significantly higher in patients with HCC than those with CHB or healthy volunteers (P<0.0001, P<0.0001, resp.).
High level of miR-21 expression correlated with cirrhosis (P=0.024) and advanced tumor stage (P=0.001).
Although serum level of miR-21 was higher in patients with HCC than in patients with CHB and healthy volunteers, the sensitivity of detection is much lower than using exosomal miR-21.
These findings indicate that miR-21 is enriched in serum exosomes which provides increased sensitivity of detection than whole serum.
Exosomal miR-21 may serve as a potential biomarker for HCC diagnosis.
American Psychological Association (APA)
Wang, Hongwei& Hou, Lijuan& Li, Aihui& Duan, Yuxiu& Gao, Haili& Song, Xinwen. 2014. Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504524
Modern Language Association (MLA)
Wang, Hongwei…[et al.]. Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-504524
American Medical Association (AMA)
Wang, Hongwei& Hou, Lijuan& Li, Aihui& Duan, Yuxiu& Gao, Haili& Song, Xinwen. Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504524