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An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population
Joint Authors
Kitsios, Georgios D.
Zintzaras, Elias
Source
International Journal of Hypertension
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified.
In this study, the association of three polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) was tested in a case-control sample of 230 patients with essential hypertension and 306 healthy controls.
Haplotype analysis was also performed.
The mutant allele a∗ of the 4a/b polymorphism showed a protective effect against hypertension under a dominant model (odds ratio=0.64, 95% confidence interval (0.44–0.93)), although this effect was not significant after the adjustment for covariates (P=0.06).
The estimated frequency of the haplotype composed of the T786∗, 4a∗, and G894∗ alleles was significantly higher in controls (5.5%) compared to cases (2%).
These results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension.
American Psychological Association (APA)
Kitsios, Georgios D.& Zintzaras, Elias. 2010. An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504538
Modern Language Association (MLA)
Kitsios, Georgios D.& Zintzaras, Elias. An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population. International Journal of Hypertension No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-504538
American Medical Association (AMA)
Kitsios, Georgios D.& Zintzaras, Elias. An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population. International Journal of Hypertension. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504538