A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites
Joint Authors
Arwert, Fré
Zwaan, Michel
Meijers-Heijboer, Hanne
de Vries, Yne
Alter, Blanche P.
Israels, Sara J.
Levitus, Marieke
Greenberg, Cheryl R.
Kuyt, Bertus
Joenje, Hans
Lwiwski, Nikki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Fanconi anemia (FA) is a recessive DNA instability disorder associated with developmental abnormalities, bone marrow failure, and a predisposition to cancer.
Based on their sensitivity to DNA cross-linking agents, FA cells have been assigned to 15 complementation groups, and the associated genes have been identified.
Founder mutations have been found in different FA genes in several populations.
The majority of Dutch FA patients belongs to complementation group FA-C.
Here, we report 15 patients of Dutch ancestry and a large Canadian Manitoba Mennonite kindred carrying the FANCC c.67delG mutation.
Genealogical investigation into the ancestors of the Dutch patients shows that these ancestors lived in four distinct areas in The Netherlands.
We also show that the Dutch and Manitoba Mennonite FANCC c.67delG patients share the same haplotype surrounding this mutation, indicating a common founder.
American Psychological Association (APA)
de Vries, Yne& Lwiwski, Nikki& Levitus, Marieke& Kuyt, Bertus& Israels, Sara J.& Arwert, Fré…[et al.]. 2012. A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites. Anemia،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504553
Modern Language Association (MLA)
de Vries, Yne…[et al.]. A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites. Anemia No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-504553
American Medical Association (AMA)
de Vries, Yne& Lwiwski, Nikki& Levitus, Marieke& Kuyt, Bertus& Israels, Sara J.& Arwert, Fré…[et al.]. A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites. Anemia. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504553