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Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors : Implications on Therapeutic Potential
Joint Authors
DelaRosa, Olga
Lombardo, Eleuterio
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs) are of special interest as therapeutic agents in the settings of both chronic inflammatory and autoimmune diseases.
Toll-like receptors (TLR) ligands have been linked with the perpetuation of inflammation in a number of chronic inflammatory diseases due to the permanent exposure of the immune system to TLR-specific stimuli.
Therefore, MSCs employed in therapy can be potentially exposed to TLR ligands, which may modulate MSC therapeutic potential in vivo.
Recent results demonstrate that MSCs are activated by TLR ligands leading to modulation of the differentiation, migration, proliferation, survival, and immunosuppression capacities.
However inconsistent results among authors have been reported suggesting that the source of MSCs, TLR stimuli employed or culture conditions play a role.
Notably, activation by TLR ligands has not been reported to modulate the “immunoprivileged” phenotype of MSCs which is of special relevance regarding the use of allogeneic MSC-based therapies.
In this review, we discuss the available data on the modulation of MSCs activity through TLR signalling.
American Psychological Association (APA)
DelaRosa, Olga& Lombardo, Eleuterio. 2010. Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors : Implications on Therapeutic Potential. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504582
Modern Language Association (MLA)
DelaRosa, Olga& Lombardo, Eleuterio. Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors : Implications on Therapeutic Potential. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-504582
American Medical Association (AMA)
DelaRosa, Olga& Lombardo, Eleuterio. Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors : Implications on Therapeutic Potential. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504582