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Regulation of Src Family Kinases in Human Cancers
Joint Authors
Sen, Banibrata
Johnson, Faye M.
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells.
Although the Src family kinases (SFKs) are activated in various types of cancers, the exact mechanisms through which they contribute to the progression of individual tumors remain to be defined.
The activation of Src in human cancers may occur through a variety of mechanisms that include domain interaction and structural remodeling in response to various activators or upstream kinases and phosphatastes.
Because of Src's prominent roles in invasion and tumor progression, epithelial-to-mesenchymal transition, angiogenesis, and the development of metastasis, Src is a promising target for cancer therapy.
Several small molecule inhibitors of Src are currently being investigated in clinical trials.
In this article, we will summarize the mechanisms regulating Src kinase activity in normal and cancer cells and discuss the status of Src inhibitor development against various types of cancers.
American Psychological Association (APA)
Sen, Banibrata& Johnson, Faye M.. 2011. Regulation of Src Family Kinases in Human Cancers. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-504601
Modern Language Association (MLA)
Sen, Banibrata& Johnson, Faye M.. Regulation of Src Family Kinases in Human Cancers. Journal of Signal Transduction No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-504601
American Medical Association (AMA)
Sen, Banibrata& Johnson, Faye M.. Regulation of Src Family Kinases in Human Cancers. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-504601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504601