The Management of Classical Hodgkin's Lymphoma : Past, Present, and Future
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The management of classical Hodgkin's lymphoma (CHL) is a success story of modern multi-agent haemato-oncology.
Prior to the middle of the twentieth century CHL was fatal in the majority of cases.
Introduction of single agent radiotherapy (RT) demonstrated for the first time that these patients could be cured.
Developments in chemotherapy including the mechlorethamine, vincristine, procarbazine and prednisolone (MOPP) and Adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) regimens have resulted in cure rates of over 80%.
Even in relapse, CHL patients can be salvaged with high dose chemotherapy and autologous haematopoietic stem cell transplantation (ASCT).
Challenges remain, however, in finding new strategies to manage the small number of patients who continue to relapse or progress.
In addition, the young age of many Hodgkin's patients forces difficult decisions in balancing the benefit of early disease control against the survival disadvantage of late toxicity.
In this article we aim to summarise past trials, define the current standard of care and appraise future developments in the management of CHL.
American Psychological Association (APA)
Richardson, S. E.& McNamara, C.. 2011. The Management of Classical Hodgkin's Lymphoma : Past, Present, and Future. Advances in Hematology،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-504606
Modern Language Association (MLA)
Richardson, S. E.& McNamara, C.. The Management of Classical Hodgkin's Lymphoma : Past, Present, and Future. Advances in Hematology No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-504606
American Medical Association (AMA)
Richardson, S. E.& McNamara, C.. The Management of Classical Hodgkin's Lymphoma : Past, Present, and Future. Advances in Hematology. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-504606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504606