Genomic Biomarkers for Personalized Medicine : Development and Validation in Clinical Studies
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The establishment of high-throughput technologies has brought substantial advances to our understanding of the biology of many diseases at the molecular level and increasing expectations on the development of innovative molecularly targeted treatments and molecular biomarkers or diagnostic tests in the context of clinical studies.
In this review article, we position the two critical statistical analyses of high-dimensional genomic data, gene screening and prediction, in the framework of development and validation of genomic biomarkers or signatures, through taking into consideration the possible different strategies for developing genomic signatures.
A wide variety of biomarker-based clinical trial designs to assess clinical utility of a biomarker or a new treatment with a companion biomarker are also discussed.
American Psychological Association (APA)
Matsui, Shigeyuki. 2013. Genomic Biomarkers for Personalized Medicine : Development and Validation in Clinical Studies. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504619
Modern Language Association (MLA)
Matsui, Shigeyuki. Genomic Biomarkers for Personalized Medicine : Development and Validation in Clinical Studies. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-504619
American Medical Association (AMA)
Matsui, Shigeyuki. Genomic Biomarkers for Personalized Medicine : Development and Validation in Clinical Studies. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504619