The Decrease of n-3 Fatty Acid Energy Percentage in an Equicaloric Diet Fed to B6C3Fe Mice for Three Generations Elicits Obesity
Joint Authors
Rivero-Covelo, Ignacio
Maloku, Ekrem
Hu, Qiaoyan
Baca, Adam
Davis, John M.
Hibbeln, Joseph R.
Hanbauer, Ingeborg
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Feeding mice, over 3 generations, an equicaloric diet in which α-linolenic acid, the dietary precursor of n-3 polyunsaturated fatty acids, was substituted by linoleic acid, the dietary precursor of n-6 polyunsaturated fatty acids, significantly increased body weight throughout life when compared with standard diet-fed mice.
Adipogenesis observed in the low n-3 fatty acid mice was accompanied by a 6-fold upregulation of stearyl-coenzyme A desaturase 1 (Scd1), whose activity is correlated to plasma triglyceride levels.
In total liver lipid and phospholipid extracts, the sum of n-3 fatty acids and the individual longer carbon chain acids, eicosapentaenoic acid (20:5n3), docosapentaenoic acid (22:5n3), and docosahexaenoic acid (22:6n3) were significantly decreased whereas arachidonic acid (20:4n6) was significantly increased.
In addition, low n-3 fatty acid-fed mice had liver steatosis, heart, and kidney hypertrophy.
Hence, reducing dietary α-linolenic acid, from 1.02 energy% to 0.16 energy% combined with raising linoleic acid intake resulted in obesity and had detrimental consequences on organ function.
American Psychological Association (APA)
Hanbauer, Ingeborg& Rivero-Covelo, Ignacio& Maloku, Ekrem& Baca, Adam& Hu, Qiaoyan& Hibbeln, Joseph R.…[et al.]. 2009. The Decrease of n-3 Fatty Acid Energy Percentage in an Equicaloric Diet Fed to B6C3Fe Mice for Three Generations Elicits Obesity. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-504623
Modern Language Association (MLA)
Hanbauer, Ingeborg…[et al.]. The Decrease of n-3 Fatty Acid Energy Percentage in an Equicaloric Diet Fed to B6C3Fe Mice for Three Generations Elicits Obesity. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-504623
American Medical Association (AMA)
Hanbauer, Ingeborg& Rivero-Covelo, Ignacio& Maloku, Ekrem& Baca, Adam& Hu, Qiaoyan& Hibbeln, Joseph R.…[et al.]. The Decrease of n-3 Fatty Acid Energy Percentage in an Equicaloric Diet Fed to B6C3Fe Mice for Three Generations Elicits Obesity. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-504623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504623