![](/images/graphics-bg.png)
Increased Stem Cell Marker Expressions during the Peri-Implantation Period in the Rat Endometrium : Constructive Role of Exogenous Zinc andor Progesterone
Joint Authors
Bakti Demiray, Sirin
Ergenoglu, Mete
Yeniel, Ahmet Ozgur
Tavmergen Goker, Ege Nazan
Demirel Sezer, Ebru
Tavmergen, Erol
Sahin, Cagdas
Oktem, Gulperi
Yilmaz Dilsiz, Ozlem
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The aim of this study is to determine the effects of zinc and/or progesterone via the expression of αvβ5 integrins and Vitronectins and embryonic stem cell markers during the peri-implantation period.
Methods.
Four experimental groups were organized.
All subjects were mated with males of the same strain to induce pregnancy; after 5 days, zinc and/or progesterone were administered.
Blood levels of zinc and progesterone were determined on the sixth day and endometrial tissues were obtained in order to evaluate the immunohistochemical expression of integrins and embryonic stem cell markers.
Results.
The αvβ5 integrin and vitronectin expression increased in the zinc group compared with the control group and no difference in the progesterone group and zinc + progesterone group.
Expression of Klf-4, Sox-2, and c-Myc was found to be increased in the zinc group compared to controls, while no difference was determined between the progesterone, zinc + progesterone, and control groups.
Distinctively, expression of the embryonic stem cell marker Oct-4 was increased in all of the experimental groups.
Conclusions.
Expression of αvβ5 integrin, vitronectin, and embryonic stem cell markers might be increased by the administration of zinc.
Our results suggest that zinc could be useful in the induction of implantation rates.
American Psychological Association (APA)
Sahin, Cagdas& Yilmaz Dilsiz, Ozlem& Bakti Demiray, Sirin& Yeniel, Ahmet Ozgur& Ergenoglu, Mete& Demirel Sezer, Ebru…[et al.]. 2014. Increased Stem Cell Marker Expressions during the Peri-Implantation Period in the Rat Endometrium : Constructive Role of Exogenous Zinc andor Progesterone. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-504633
Modern Language Association (MLA)
Sahin, Cagdas…[et al.]. Increased Stem Cell Marker Expressions during the Peri-Implantation Period in the Rat Endometrium : Constructive Role of Exogenous Zinc andor Progesterone. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-504633
American Medical Association (AMA)
Sahin, Cagdas& Yilmaz Dilsiz, Ozlem& Bakti Demiray, Sirin& Yeniel, Ahmet Ozgur& Ergenoglu, Mete& Demirel Sezer, Ebru…[et al.]. Increased Stem Cell Marker Expressions during the Peri-Implantation Period in the Rat Endometrium : Constructive Role of Exogenous Zinc andor Progesterone. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-504633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504633