Lenalidomide, Melphalan, and Prednisone Association Is an Effective Salvage Therapy in Relapsed Plasma Cell Leukaemia
Joint Authors
Saglio, Giuseppe
Merlini, Roberta
Guglielmelli, Tommasina
Giugliano, Emilia
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-17
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
Plasma cell leukemia (PCL) is a rare and aggressive plasma cell disorder, characterized by the presence of a peripheral blood absolute plasma cell count of at least 2×109/l and more than 20% circulating plasma cells.
The prognosis of PCL patients remains poor.
Even by using autologous or allogenic transplant procedures, median survival does not exceed 3 years (Saccaro et al., 2005).
Thalidomide, bortezomib and lenalidomide (Revlimid) have emerged as high active agents in the treatment of PCL (Johnston and abdalla, 2002; Musto et al., 2007; Finnegan et al., 2006).
In particular, Lenalidomide is a structural analogue of thalidomide with similar but more potent biological activity; it is used as first line therapy in MM (Palumbo et al., 2007; Niesvizky et al., 2007), although information regarding its associated use with dexamethasone use as salvage therapy in PCL derives from anecdotal single case reports (Musto et al., 2008).
We would like to describe a case of primary PCL with adverse cytogenetic in which excellent response was achieved with the combination of lenalidomide, melphalan, and prednisone as salvage therapy.
American Psychological Association (APA)
Guglielmelli, Tommasina& Merlini, Roberta& Giugliano, Emilia& Saglio, Giuseppe. 2009. Lenalidomide, Melphalan, and Prednisone Association Is an Effective Salvage Therapy in Relapsed Plasma Cell Leukaemia. Journal of Oncology،Vol. 2009, no. 2009, pp.1-2.
https://search.emarefa.net/detail/BIM-504656
Modern Language Association (MLA)
Guglielmelli, Tommasina…[et al.]. Lenalidomide, Melphalan, and Prednisone Association Is an Effective Salvage Therapy in Relapsed Plasma Cell Leukaemia. Journal of Oncology No. 2009 (2009), pp.1-2.
https://search.emarefa.net/detail/BIM-504656
American Medical Association (AMA)
Guglielmelli, Tommasina& Merlini, Roberta& Giugliano, Emilia& Saglio, Giuseppe. Lenalidomide, Melphalan, and Prednisone Association Is an Effective Salvage Therapy in Relapsed Plasma Cell Leukaemia. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-2.
https://search.emarefa.net/detail/BIM-504656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504656