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Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
Joint Authors
Popov, Victor I.
Stewart, Michael G.
Ignat'ev, Dmitri A.
Kraev, Igor V.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory.
Hibernation in Siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h (from 35-36°C to +4–6°C) permits accumulation of mitotic cells at different stages of the cell cycle.
Histological methods used to study adult neurogenesis are limited largely to fixed tissue, and the mitotic state elucidated depends on the specific phase of mitosis at the time of day.
However, using an immunohistochemical study of doublecortin (DCX) and BrdU-labelled neurons, we demonstrate that the dentate gyrus of the ground squirrel hippocampus contains a population of immature cells which appear to possess mitotic activity.
Our data suggest that doublecortin-labelled immature cells exist in a mitotic state and may represent a renewable pool for generation of new neurons within the dentate gyrus.
American Psychological Association (APA)
Popov, Victor I.& Kraev, Igor V.& Ignat'ev, Dmitri A.& Stewart, Michael G.. 2011. Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel. Neural Plasticity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504677
Modern Language Association (MLA)
Popov, Victor I.…[et al.]. Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel. Neural Plasticity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-504677
American Medical Association (AMA)
Popov, Victor I.& Kraev, Igor V.& Ignat'ev, Dmitri A.& Stewart, Michael G.. Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504677