Angiogenesis-Related Cytokines, RANKL, and Osteoprotegerin in Multiple Myeloma Patients in relation to Clinical Features and Response to Treatment
Joint Authors
Sakellaris, G.
Alexandrakis, Michael G.
Sfiridaki, K.
Kaparou, Maria
Stratinaki, M.
Pappa, C. A.
Kanellou, Peggy
Kontakis, G.
Tsirakis, George
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
An essential cytokine system for the osteoclast biology in multiple myeloma (MM) consists of the receptor of activator of NF-κB ligand (RANKL), its receptor (RANK), and the soluble decoy receptor, osteoprotegerin (OPG).
Myeloma cells cause imbalance in OPG/RANKL interactions.
We measured serum levels of OPG, soluble (s) RANKL, sRANKL/OPG ratio, markers of disease activity [LDH, CRP, interleukin-6 (IL-6), β2-microglobulin (B2M)], and angiogenic factors [hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF)], in 54 newly diagnosed MM patients and in 25 of them in plateau phase.
All the above values were higher in MM patients compared to controls and decreased in plateau phase.
sRANKL and RANKL/OPG were higher with advancing disease stage and skeletal grade.
Significant correlations were found among RANKL and RANKL/OPG with HGF, LDH, VEGF, IL-6, and B2M.
In conclusion, RANKL and OPG play significant roles in MM pathophysiology, as regulators of bone turnover and mediators of angiogenesis.
American Psychological Association (APA)
Sfiridaki, K.& Pappa, C. A.& Tsirakis, George& Kanellou, Peggy& Kaparou, Maria& Stratinaki, M.…[et al.]. 2011. Angiogenesis-Related Cytokines, RANKL, and Osteoprotegerin in Multiple Myeloma Patients in relation to Clinical Features and Response to Treatment. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504684
Modern Language Association (MLA)
Sfiridaki, K.…[et al.]. Angiogenesis-Related Cytokines, RANKL, and Osteoprotegerin in Multiple Myeloma Patients in relation to Clinical Features and Response to Treatment. Mediators of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-504684
American Medical Association (AMA)
Sfiridaki, K.& Pappa, C. A.& Tsirakis, George& Kanellou, Peggy& Kaparou, Maria& Stratinaki, M.…[et al.]. Angiogenesis-Related Cytokines, RANKL, and Osteoprotegerin in Multiple Myeloma Patients in relation to Clinical Features and Response to Treatment. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504684