Safety and Tolerability of Antiretrovirals during Pregnancy
Joint Authors
Soda, Elizabeth
Forster-Harwood, Jeri
Salbenblatt, Carol
Davies, Jill
McFarland, Elizabeth J.
Barr, Emily
Vazquez, Anna
Pappas, Jennifer
Levin, Myron J.
Paul, Suzanne
Kinzie, Kay
Weinberg, Adriana
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Combination antiretroviral therapy (CART) dramatically decreases mother-to-child HIV-1 transmission (MTCT), but maternal adverse events are not infrequent.
A review of 117 locally followed pregnancies revealed 7 grade ≥3 AEs possibly related to antiretrovirals, including 2 hematologic, 3 hepatic, and 2 obstetric cholestasis cases.
A fetal demise was attributed to obstetric cholestasis, but no maternal deaths occurred.
The drugs possibly associated with these AE were zidovudine, nelfinavir, lopinavir/ritonavir, and indinavir.
AE or intolerability required discontinuation/substitution of nevirapine in 16% of the users, zidovudine in 10%, nelfinavir in 9%, lopinavir/ritonavir in 1%, but epivir and stavudine in none.
In conclusion, nevirapine, zidovudine, and nelfinavir had the highest frequency of AE and/or the lowest tolerability during pregnancy.
Although nevirapine and nelfinavir are infrequently used in pregnancy at present, zidovudine is included in most MTCT preventative regimens.
Our data emphasize the need to revise the treatment recommendations for pregnant women to include safer and better-tolerated drugs.
American Psychological Association (APA)
Weinberg, Adriana& Forster-Harwood, Jeri& Davies, Jill& McFarland, Elizabeth J.& Pappas, Jennifer& Kinzie, Kay…[et al.]. 2011. Safety and Tolerability of Antiretrovirals during Pregnancy. Infectious Diseases in Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504694
Modern Language Association (MLA)
Weinberg, Adriana…[et al.]. Safety and Tolerability of Antiretrovirals during Pregnancy. Infectious Diseases in Obstetrics and Gynecology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-504694
American Medical Association (AMA)
Weinberg, Adriana& Forster-Harwood, Jeri& Davies, Jill& McFarland, Elizabeth J.& Pappas, Jennifer& Kinzie, Kay…[et al.]. Safety and Tolerability of Antiretrovirals during Pregnancy. Infectious Diseases in Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504694