Combinational Effects of Prebiotics and Soybean against Azoxymethane-Induced Colon Cancer In Vivo

Abstract EN

Prebiotic fructans are nondigestible carbohydrates with numerous health benefits.

Soybean is a rich source of phytonutrients such as isoflavones.

The objective of this study was to evaluate the chemopreventive effects of prebiotics (Synergy1) and soybean meal (SM) at 5% and 10% levels alone and in combination on azoxymethane- (AOM-) induced colon carcinogenesis.

After one wk of acclimatization, Fisher 344 male rats (N=90) were randomly assigned to 9 groups (n=10).

Control rats (C) were fed AIN-93G/M.

Two s/c injections of AOM were administered to rats at 7 and 8 wk of age at 16 mg/kg body weight.

Rats were killed by CO2 asphyxiation at 45 wk.

Tumor incidence (%) in treatment groups ranged from 40 to 75 compared to 100 in C.

Results indicate that feeding prebiotics and soybean in combination significantly reduced incidence of AOM-induced colon tumors with implications for food industry in the food-product development.