High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
Joint Authors
Behnia, Fatemeh
Yosefi-Oudarji, Ali
Sivberg, Bengt
Brudin, Lars
Nordström, Berit
Joghataei, Mohammad T.
Momeni, Naghi
Persson, Bengt L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders.
ASD is also associated with immune system abnormality.
Immune system abnormalities may be caused partly by complement system factor I deficiency.
Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system.
Deficiency in factor I activity is associated with an increased incidence of infections in humans.
In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD.
American Psychological Association (APA)
Momeni, Naghi& Brudin, Lars& Behnia, Fatemeh& Nordström, Berit& Yosefi-Oudarji, Ali& Sivberg, Bengt…[et al.]. 2011. High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders. Autism Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504770
Modern Language Association (MLA)
Momeni, Naghi…[et al.]. High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders. Autism Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-504770
American Medical Association (AMA)
Momeni, Naghi& Brudin, Lars& Behnia, Fatemeh& Nordström, Berit& Yosefi-Oudarji, Ali& Sivberg, Bengt…[et al.]. High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders. Autism Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504770