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The Role of TNPO3 in HIV-1 Replication
Author
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
TNPO3, transportin-SR2 or Tnp3, a member of the karyopherin β superfamily of proteins, is important for the ability of human immunodeficiency virus (HIV-1) to achieve productive infection, as TNPO3 depletion in human cells leads to a dramatic reduction of infection.
Here we describe and discuss recent findings suggesting that TNPO3 assists HIV-1 replication in the nucleus and in fact that TNPO3 may assist PIC maturation in the nucleus.
In addition, the viral determinant for the requirement of TNPO3 in HIV-1 infection is discussed.
This paper summarizes the most significant recent discoveries about this important host factor and its role in HIV-1 replication.
American Psychological Association (APA)
Diaz-Griffero, Felipe. 2012. The Role of TNPO3 in HIV-1 Replication. Molecular Biology International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504771
Modern Language Association (MLA)
Diaz-Griffero, Felipe. The Role of TNPO3 in HIV-1 Replication. Molecular Biology International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-504771
American Medical Association (AMA)
Diaz-Griffero, Felipe. The Role of TNPO3 in HIV-1 Replication. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504771