H-Ras Oncogene Expression and Angiogenesis in Experimental Liver Cirrhosis
Joint Authors
Bozova, Sevgi
Elpek, Gülsüm Özlem
Ünal, Betül
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-22
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Proto-oncogenes, particularly ras, may not only affect cell proliferation but also contribute to angiogenesis by influencing both proangiogenic and antiangiogenic mediators.
The aim of this study was to investigate whether any relationship exists between ras expression and angiogenesis during diethylnitrosamine- (DEN-) induced experimental liver fibrosis.
Materials and Methods.
Liver cirrhosis was induced in rats by intraperitoneal injections of DEN.
The animals were sacrificed 2 weeks after the last administrations and a hepatectomy was performed.
Masson’s trichrome staining was used in the evaluation of the extent of liver fibrosis.
The vascular density in portal and periportal areas was assessed by determining the count of CD34 labeled vessel sections.
For quantitative evaluation of H-ras expression, in each section positive and negative cells were counted.
Results.
In fibrotic group H-ras expression was higher than that in nonfibrotic group and was more widespread in cirrhotic livers.
Friedman’s test showed that there was a significant correlation between H-ras expression and VD (P<0.01).
Conclusion.
The results of this descriptive study reveal that H-ras expression gradually increases according to the severity of fibrosis and strongly correlates with angiogenesis.
American Psychological Association (APA)
Elpek, Gülsüm Özlem& Ünal, Betül& Bozova, Sevgi. 2013. H-Ras Oncogene Expression and Angiogenesis in Experimental Liver Cirrhosis. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-504783
Modern Language Association (MLA)
Elpek, Gülsüm Özlem…[et al.]. H-Ras Oncogene Expression and Angiogenesis in Experimental Liver Cirrhosis. Gastroenterology Research and Practice No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-504783
American Medical Association (AMA)
Elpek, Gülsüm Özlem& Ünal, Betül& Bozova, Sevgi. H-Ras Oncogene Expression and Angiogenesis in Experimental Liver Cirrhosis. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-504783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504783