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Systemic Lupus Erythematosus : Recent Concepts in Genomics, Pathogenetic Mechanisms, and Therapies
Joint Authors
Mahadevan, Subramanian
Krishnamurthy, Sriram
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder associated with multiple immunological abnormalities and a wide range of clinical manifestations.
Recent progress in genetics has expanded the number of the genes associated with SLE to more than 20 in number and has contributed to improvement of understanding of the pathogenesis of the disease.
This has enhanced the development of novel therapeutic targets and biomarkers for individualized and tailor-made clinical management of lupus patients.
Despite this knowledge, however, it is a challenge to fully understand the genetic pathogenesis of the disease.
The present paper describes the current concepts in the mechanisms, genomics, and pathogenesis of SLE and their implications for management of the disorder.
The potential role of gene therapy, biological agents, intravenous immunoglobulin, anti-inflammatory cytokines, and cytokine inhibitors is discussed.
American Psychological Association (APA)
Krishnamurthy, Sriram& Mahadevan, Subramanian. 2011. Systemic Lupus Erythematosus : Recent Concepts in Genomics, Pathogenetic Mechanisms, and Therapies. ISRN Immunology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504786
Modern Language Association (MLA)
Krishnamurthy, Sriram& Mahadevan, Subramanian. Systemic Lupus Erythematosus : Recent Concepts in Genomics, Pathogenetic Mechanisms, and Therapies. ISRN Immunology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-504786
American Medical Association (AMA)
Krishnamurthy, Sriram& Mahadevan, Subramanian. Systemic Lupus Erythematosus : Recent Concepts in Genomics, Pathogenetic Mechanisms, and Therapies. ISRN Immunology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504786