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Breath Ketone Testing : A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
Joint Authors
Gao, Zhaohua
Duan, Yixiang
Cheng, Yan
Liu, Yu
Qiao, Yue
Zhao, Lingling
Yu, Mengxiao
Liu, Yong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Acetone, β-hydroxybutyric acid, and acetoacetic acid are three types of ketone body that may be found in the breath, blood, and urine.
Detecting altered concentrations of ketones in the breath, blood, and urine is crucial for the diagnosis and treatment of diabetic ketosis.
The aim of this study was to evaluate the advantages of different detection methods for ketones, and to establish whether detection of the concentration of ketones in the breath is an effective and practical technique.
Methods.
We measured the concentrations of acetone in the breath using gas chromatography-mass spectrometry and β-hydroxybutyrate in fingertip blood collected from 99 patients with diabetes assigned to groups 1 (−), 2 (±), 3 (+), 4 (++), or 5 (+++) according to urinary ketone concentrations.
Results.
There were strong relationships between fasting blood glucose, age, and diabetic ketosis.
Exhaled acetone concentration significantly correlated with concentrations of fasting blood glucose, ketones in the blood and urine, LDL-C, creatinine, and blood urea nitrogen.
Conclusions.
Breath testing for ketones has a high sensitivity and specificity and appears to be a noninvasive, convenient, and repeatable method for the diagnosis and therapeutic monitoring of diabetic ketosis.
American Psychological Association (APA)
Qiao, Yue& Gao, Zhaohua& Liu, Yong& Cheng, Yan& Yu, Mengxiao& Zhao, Lingling…[et al.]. 2014. Breath Ketone Testing : A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504811
Modern Language Association (MLA)
Qiao, Yue…[et al.]. Breath Ketone Testing : A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-504811
American Medical Association (AMA)
Qiao, Yue& Gao, Zhaohua& Liu, Yong& Cheng, Yan& Yu, Mengxiao& Zhao, Lingling…[et al.]. Breath Ketone Testing : A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504811