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Biocompatibility Issues of Next Generation Decellularized Bioprosthetic Devices
Joint Authors
Dettin, Monica
Naso, Filippo
Zancan, Irene
Spina, Michele
Gerosa, Gino
Iop, Laura
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
With respect to the limited lifespan of glutaraldehyde-treated bioprostheses (BHVs) to date there is almost no alternative when heart valve replacement surgery is required and most advanced current research attempts to develop tissue engineered valve scaffolds to be implanted in vivo or after in vitro preconditioning and dynamic seeding with host cells.
However the clinical outcomes of grafting detergent-based cell-depleted tissue engineered xenogeneic constructs are still controversial.
Insufficient quantitative evaluations performed at preclinical level about the residual content of xenogeneic epitopes, detergents, and nucleic acid materials in such scaffolds have led to disappointing and disastrous results.
The risk of these dramatic accidents reoccurring remains very high unless safety and reliable control tools aimed to reach their complete removal, in order to consider tissues biocompatible and suitable for clinical practice.
American Psychological Association (APA)
Spina, Michele& Naso, Filippo& Zancan, Irene& Iop, Laura& Dettin, Monica& Gerosa, Gino. 2014. Biocompatibility Issues of Next Generation Decellularized Bioprosthetic Devices. Conference Papers in Science،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-504815
Modern Language Association (MLA)
Spina, Michele…[et al.]. Biocompatibility Issues of Next Generation Decellularized Bioprosthetic Devices. Conference Papers in Science No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-504815
American Medical Association (AMA)
Spina, Michele& Naso, Filippo& Zancan, Irene& Iop, Laura& Dettin, Monica& Gerosa, Gino. Biocompatibility Issues of Next Generation Decellularized Bioprosthetic Devices. Conference Papers in Science. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-504815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504815