Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

Author

Upadhyay, Ravi Kant

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-37, 37 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-07-20

Country of Publication

Egypt

No. of Pages

37

Main Subjects

Medicine

Abstract EN

Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics.

In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs, radiopharmaceuticals, proteins, immunoglobulins, and chimeric peptides to the target sites in deep tissue locations inside tumor sites of brain has been explained.

In addition, therapeutic applications of various types of nanoparticles such as chitosan based nanomers, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers, cholesterol mediated cationic solid lipid nanoparticles, colloidal drug carriers, liposomes, and micelles have been discussed with their recent advancements.

Emphasis has been given on the need of physiological and therapeutic optimization of existing drug delivery methods and their carriers to deliver therapeutic amount of drug into the brain for treatment of various neurological diseases and disorders.

Further, strong recommendations are being made to develop nanosized drug carriers/vehicles and noninvasive therapeutic alternatives of conventional methods for better therapeutics of CNS related diseases.

Hence, there is an urgent need to design nontoxic biocompatible drugs and develop noninvasive delivery methods to check posttreatment clinical fatalities in neuropatients which occur due to existing highly toxic invasive drugs and treatment methods.

American Psychological Association (APA)

Upadhyay, Ravi Kant. 2014. Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier. BioMed Research International،Vol. 2014, no. 2014, pp.1-37.
https://search.emarefa.net/detail/BIM-504819

Modern Language Association (MLA)

Upadhyay, Ravi Kant. Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier. BioMed Research International No. 2014 (2014), pp.1-37.
https://search.emarefa.net/detail/BIM-504819

American Medical Association (AMA)

Upadhyay, Ravi Kant. Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-37.
https://search.emarefa.net/detail/BIM-504819

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-504819