Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats
Joint Authors
Gupta, Malaya
Bala, Asis
Haldar, Pallab K.
KunduSen, Sriparna
Mazumder, Upal K.
Bhattacharya, Sanjib
Kar, Biswakanth
Saha, Prerona
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats.
Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg-1 body weight daily for 15 days.
Glibenclamide (0.5 mg kg-1 p.
o.) was used as reference drug.
Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study.
Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated.
The TBARS and GSH levels of pancreas, kidney, and liver were determined.
MECL significantly (P<0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control.
The present paper infers that in STZ-induced diabetic Wistar rats, C.
limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.
American Psychological Association (APA)
KunduSen, Sriparna& Haldar, Pallab K.& Gupta, Malaya& Mazumder, Upal K.& Saha, Prerona& Bala, Asis…[et al.]. 2011. Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504820
Modern Language Association (MLA)
KunduSen, Sriparna…[et al.]. Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats. ISRN Endocrinology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-504820
American Medical Association (AMA)
KunduSen, Sriparna& Haldar, Pallab K.& Gupta, Malaya& Mazumder, Upal K.& Saha, Prerona& Bala, Asis…[et al.]. Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504820
