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Receptor Tyrosine Kinases in Kidney Development
Joint Authors
El-Dahr, Samir S.
Song, Renfang
Yosypiv, Ihor V.
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The kidney plays a fundamental role in the regulation of arterial blood pressure and fluid/electrolyte homeostasis.
As congenital anomalies of the kidney and urinary tract (CAKUT) constitute one of the most common human birth defects, improved understanding of the cellular and molecular mechanisms that lead to CAKUT is critical.
Accumulating evidence indicates that aberrant signaling via receptor tyrosine kinases (RTKs) is causally linked to CAKUT.
Upon activation by their ligands, RTKs dimerize, undergo autophosphorylation on specific tyrosine residues, and interact with adaptor proteins to activate intracellular signal transduction pathways that regulate diverse cell behaviours such as cell proliferation, survival, and movement.
Here, we review the current understanding of role of RTKs and their downstream signaling pathways in the pathogenesis of CAKUT.
American Psychological Association (APA)
Song, Renfang& El-Dahr, Samir S.& Yosypiv, Ihor V.. 2011. Receptor Tyrosine Kinases in Kidney Development. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-504822
Modern Language Association (MLA)
Song, Renfang…[et al.]. Receptor Tyrosine Kinases in Kidney Development. Journal of Signal Transduction No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-504822
American Medical Association (AMA)
Song, Renfang& El-Dahr, Samir S.& Yosypiv, Ihor V.. Receptor Tyrosine Kinases in Kidney Development. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-504822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504822