Lectin from Crataeva tapia Bark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice
Joint Authors
Mota, Diógenes Luís da
Lima, Vera Lúcia de Menezes
Rocha, Amanda Alves da
Correia, Maria Tereza dos Santos
Medeiros, Paloma Lys de
Paiva, Patrícia Maria Guedes
Araújo, Tiago Ferreira da Silva
Cassandra Breitenbach Barroso Coelho, Luana
Fonseca, Caíque Silveira Martins da
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Crataeva tapia is a plant popularly used for diabetes treatment, in Brazil.
Progressive decline in renal and hepatic functions has been described in patients with diabetes mellitus, and mortality rate is increased in patients with chronic liver and renal disease.
This study aimed to evaluate whether Crataeva tapia bark lectin (CrataBL) improves hyperglycemia and renal and hepatic damage in diabetic mice.
CrataBL was purified by ion exchange chromatography on CM-cellulose, and intraperitoneal administration of CrataBL to alloxan-induced diabetic mice at dose of 10 mg/Kg/day and 20 mg/Kg/day for 10 days significantly reduced serum glucose levels by 14.9% and 55.9%, respectively.
Serum urea, creatinine, aspartate aminotransferase, and alanine aminotransferase were also significantly reduced after treatment with both doses of CrataBL.
Furthermore, histological analysis of liver, kidney, and pancreas revealed an improvement in the tissue morphology upon treatment with CrataBL.
The results suggest that CrataBL has a beneficial hypoglycemic activity and improves the renal and hepatic complications of diabetes.
Therefore, this lectin may be a promising agent for the treatment of diabetes, and this might be the basis for its use in the folk medicine as an alternative treatment to manage diabetes-related complications such as hyperglycemia and tissue damage.
American Psychological Association (APA)
Rocha, Amanda Alves da& Araújo, Tiago Ferreira da Silva& Fonseca, Caíque Silveira Martins da& Mota, Diógenes Luís da& Medeiros, Paloma Lys de& Paiva, Patrícia Maria Guedes…[et al.]. 2013. Lectin from Crataeva tapia Bark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504824
Modern Language Association (MLA)
Rocha, Amanda Alves da…[et al.]. Lectin from Crataeva tapia Bark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-504824
American Medical Association (AMA)
Rocha, Amanda Alves da& Araújo, Tiago Ferreira da Silva& Fonseca, Caíque Silveira Martins da& Mota, Diógenes Luís da& Medeiros, Paloma Lys de& Paiva, Patrícia Maria Guedes…[et al.]. Lectin from Crataeva tapia Bark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504824