The Time Course Effects of Electroacupuncture on Promoting Skeletal Muscle Regeneration and Inhibiting Excessive Fibrosis after Contusion in Rabbits
Joint Authors
Luo, Dan
Liu, Shouyao
Lin, Peng
Wang, Yunting
Wang, Rongguo
Xu, Qianwei
Xiao, Cheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The aim of this study was to investigate the longitudinal effects of electroacupuncture (EA) on Zusanli (ST36) and Ashi acupoints in promoting skeletal muscle regeneration and inhibiting excessive fibrosis after contusion in rabbits.
Sixty rabbits were randomly divided into four groups: normal, contusion, EA, and recombinant human insulin-like growth factor-I (rhIGF-I).
An acute skeletal muscle contusion was produced on the right gastrocnemius (GM) by an instrument-based drop-mass technique.
EA was performed for 15 minutes every two days with 0.4 mA (2 Hz), and GM injections were executed with rhIGF-I (0.25 mL once a week).
Rabbits treated with EA had a higher T-SOD and T-AOC serum activities and lower MDA serum level, the blood perfusion of which was also significantly higher.
In the EA group, the diameter of the myofibril was uniform and the arrangement was regular, contrary to the contusion group.
The number and diameter of regenerative myofibers and MHC expression were increased in the EA group.
EA treatment significantly decreased fibrosis formation and reduced both GDF-8 and p-Smad2/3 expressions in injured muscle.
Our data indicate that EA may promote myofiber regeneration and reduce excessive fibrosis by improving blood flow and antioxidant capacities.
Additionally, EA may regulate signaling factor expression after contusion.
American Psychological Association (APA)
Wang, Rongguo& Luo, Dan& Xiao, Cheng& Lin, Peng& Liu, Shouyao& Xu, Qianwei…[et al.]. 2013. The Time Course Effects of Electroacupuncture on Promoting Skeletal Muscle Regeneration and Inhibiting Excessive Fibrosis after Contusion in Rabbits. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-504833
Modern Language Association (MLA)
Wang, Rongguo…[et al.]. The Time Course Effects of Electroacupuncture on Promoting Skeletal Muscle Regeneration and Inhibiting Excessive Fibrosis after Contusion in Rabbits. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-504833
American Medical Association (AMA)
Wang, Rongguo& Luo, Dan& Xiao, Cheng& Lin, Peng& Liu, Shouyao& Xu, Qianwei…[et al.]. The Time Course Effects of Electroacupuncture on Promoting Skeletal Muscle Regeneration and Inhibiting Excessive Fibrosis after Contusion in Rabbits. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-504833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504833