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Myelofibrosis-Related Arthritis Successfully Treated with Hydroxyurea
Joint Authors
Vidon, Claire
Wendling, Daniel
Guillot, Xavier
Moldovan, Marius
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
A 62-year-old woman suffering from one-year lasting, nonerosive peripheral arthritides with general health impairment and high acute-phase reactant levels was admitted to rheumatology department.
The patient had suffered from chronic polyarthralgia and a thrombocytosis had been discovered 9 years before, with a recent increase in platelet count.
All immunological blood tests were negative.
Corticosteroid and methotrexate treatments improved pain, swollen joint count, and systemic inflammation.
However, joints remained stiff and painful with two swollen wrists and persistent thrombocytosis.
An iliac bone marrow biopsy was performed, showing primary myelofibrosis.
Hydroxyurea treatment (500 mg per day) allowed to achieve complete and prolonged clinical and biological remission.
After 6 months, a new disease flare occurred.
The patient reached remission again after hydroxyurea dose increased to 1500 mg per day.
This supports the hypothesis of idiopathic myelofibrosis-associated seronegative polyarthritis.
This is the first reported case in which haemopathy-targeted treatment using hydroxyurea induced arthritis remission.
American Psychological Association (APA)
Guillot, Xavier& Moldovan, Marius& Vidon, Claire& Wendling, Daniel. 2014. Myelofibrosis-Related Arthritis Successfully Treated with Hydroxyurea. Case Reports in Rheumatology،Vol. 2014, no. 2014, pp.1-2.
https://search.emarefa.net/detail/BIM-504870
Modern Language Association (MLA)
Guillot, Xavier…[et al.]. Myelofibrosis-Related Arthritis Successfully Treated with Hydroxyurea. Case Reports in Rheumatology No. 2014 (2014), pp.1-2.
https://search.emarefa.net/detail/BIM-504870
American Medical Association (AMA)
Guillot, Xavier& Moldovan, Marius& Vidon, Claire& Wendling, Daniel. Myelofibrosis-Related Arthritis Successfully Treated with Hydroxyurea. Case Reports in Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-2.
https://search.emarefa.net/detail/BIM-504870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504870