Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil
Joint Authors
Prajapati, Shailesh T.
Dumaniya, Suresh K.
Bulchandani, Hitesh H.
Patel, Chhaganbhai N.
Patel, Dasharath M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally.
It is highly lipophilic (log P 5.5) and a poorly water-soluble drug with absolute bioavailability of 26%.
The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry.
The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate.
Liquisolid compacts were prepared using Acrysol El 135 as a solvent, Avicel PH 102, Fujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios.
The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients.
The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial limits.
The dissolution studies for liquisolid compacts and conventional formulations were carried out, and it was found that liquisolid compacts with 80% w/w of Acrysol EL 135 to the drug showed significant higher drug release rates than conventional tablets.
Amongst carriers used Fujicalin and Neusilin were found to be more effective carrier materials for liquid adsorption.
American Psychological Association (APA)
Prajapati, Shailesh T.& Bulchandani, Hitesh H.& Patel, Dasharath M.& Dumaniya, Suresh K.& Patel, Chhaganbhai N.. 2013. Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504926
Modern Language Association (MLA)
Prajapati, Shailesh T.…[et al.]. Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil. Journal of Drug Delivery No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-504926
American Medical Association (AMA)
Prajapati, Shailesh T.& Bulchandani, Hitesh H.& Patel, Dasharath M.& Dumaniya, Suresh K.& Patel, Chhaganbhai N.. Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504926