Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China
Joint Authors
Wu, Chun-Feng
Wu, Gui Sheng
Li, Xiao-Lan
Source
International Journal of Genomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors.
The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis.
In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age- and sex-matched control subjects were enrolled.
Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects.
We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs: IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups.
Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population.
The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27–0.96) in Chinese.
Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R.
Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population.
American Psychological Association (APA)
Li, Xiao-Lan& Wu, Chun-Feng& Wu, Gui Sheng. 2014. Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504929
Modern Language Association (MLA)
Li, Xiao-Lan…[et al.]. Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China. International Journal of Genomics No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-504929
American Medical Association (AMA)
Li, Xiao-Lan& Wu, Chun-Feng& Wu, Gui Sheng. Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504929