The Role of Histone Ubiquitination during Spermatogenesis
Joint Authors
Liang, Xiaotong
Huang, Sizhou
Xu, Wenming
Sheng, Kai
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Protein ubiquitin-proteasome (ubiquitin-proteasome) system is the major mechanism responsible for protein degradation in eukaryotic cell.
During spermatogenesis, the replacement of histone by protamine is vital for normal sperm formation, which is involved in ubiquitination enzymes expressed in testis.
Recently, histone ubiquitin ligases have been shown to play critical roles in several aspects of spermatogenesis, such as meiotic sex chromosome inactivation (MSCI), DNA damage response, and spermiogenesis.
In this review, we highlight recent progress in the discovery of several histone ubiquitin ligases and elaborate mechanisms of how these enzymes are involved in these processes through knockout mouse model.
Using Huwe1, UBR2, and RNF8 as examples, we emphasized the diverse functions for each enzyme and the broad involvement of these enzymes in every stage, from spermatogonia differentiation and meiotic division to spermiogenesis; thus histone ubiquitin ligases represent a class of enzymes, which play important roles in spermatogenesis through targeting histone for ubiquitination and therefore are involved in transcription regulation, epigenetic modification, and other processes essential for normal gametes formation.
American Psychological Association (APA)
Sheng, Kai& Liang, Xiaotong& Huang, Sizhou& Xu, Wenming. 2014. The Role of Histone Ubiquitination during Spermatogenesis. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-504938
Modern Language Association (MLA)
Sheng, Kai…[et al.]. The Role of Histone Ubiquitination during Spermatogenesis. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-504938
American Medical Association (AMA)
Sheng, Kai& Liang, Xiaotong& Huang, Sizhou& Xu, Wenming. The Role of Histone Ubiquitination during Spermatogenesis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-504938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504938