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Distribution of 5-Hydroxymethylcytosine in Different Human Tissues
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
5-hydroxymethylcytosine (5-hmC) is a modified form of cytosine recently found in mammalians and is believed, like 5-methylcytosine, to also play an important role in switching genes on and off.
By utilizing a newly developed 5-hmC immunoassay, we determined the abundance of 5-hmC in human tissues and compared 5-hmC states in normal colorectal tissue and cancerous colorectal tissue.
Significant differences of 5-hmC content in different tissues were observed.
The percentage of 5-hmC measured is high in brain, liver, kidney and colorectal tissues (0.40–0.65%), while it is relatively low in lung (0.18%) and very low in heart, breast, and placenta (0.05-0.06%).
Abundance of 5-hmC in the cancerous colorectal tissues was significantly reduced (0.02–0.06%) compared to that in normal colorectal tissues (0.46–0.57%).
Our results showed for the first time that 5-hmC distribution is tissue dependent in human tissues and its abundance could be changed in the diseased states such as colorectal cancer.
American Psychological Association (APA)
Li, Weiwei& Liu, Min. 2011. Distribution of 5-Hydroxymethylcytosine in Different Human Tissues. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-504940
Modern Language Association (MLA)
Li, Weiwei& Liu, Min. Distribution of 5-Hydroxymethylcytosine in Different Human Tissues. Journal of Nucleic Acids No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-504940
American Medical Association (AMA)
Li, Weiwei& Liu, Min. Distribution of 5-Hydroxymethylcytosine in Different Human Tissues. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-504940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504940