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Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
Joint Authors
Verhoog, Matthijs B.
Mansvelder, Huibert D.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Throughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience.
In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond timing of action potential firing (STDP).
The sign of synaptic plasticity depends on the spike order of presynaptic and postsynaptic neurons.
Ionotropic neurotransmitter receptors, such as NMDA receptors and nicotinic acetylcholine receptors, are intimately involved in setting the rules for synaptic strengthening and weakening.
In addition, timing rules for STDP within synapses are not fixed.
They can be altered by activation of ionotropic receptors located at, or close to, synapses.
Here, we will highlight studies that uncovered how network actions control and modulate timing rules for STDP by activating presynaptic ionotropic receptors.
Furthermore, we will discuss how interaction between different types of ionotropic receptors may create “timing” windows during which particular timing rules lead to synaptic changes.
American Psychological Association (APA)
Verhoog, Matthijs B.& Mansvelder, Huibert D.. 2011. Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity. Neural Plasticity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-504942
Modern Language Association (MLA)
Verhoog, Matthijs B.& Mansvelder, Huibert D.. Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity. Neural Plasticity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-504942
American Medical Association (AMA)
Verhoog, Matthijs B.& Mansvelder, Huibert D.. Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-504942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504942