Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization

Joint Authors

Liu, Po-Len
Chen, Huey-Yi
Chen, Wen-Chi
Lin, Yi-Wen
Man, Kee-Ming
Wang, Shu-Huei
Chen, Yuh-Lien
Liu, Jung-Tung
Yin, Wei-Hsian
Wang, Hui-Min
Chen, Yung-Hsiang

Source

Journal of Biomedicine and Biotechnology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-05-22

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells.

It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities.

PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties.

More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization.

Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells.

PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease.

Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases.

Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization.

American Psychological Association (APA)

Liu, Jung-Tung& Chen, Yuh-Lien& Chen, Wen-Chi& Chen, Huey-Yi& Lin, Yi-Wen& Wang, Shu-Huei…[et al.]. 2012. Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-504994

Modern Language Association (MLA)

Liu, Jung-Tung…[et al.]. Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-504994

American Medical Association (AMA)

Liu, Jung-Tung& Chen, Yuh-Lien& Chen, Wen-Chi& Chen, Huey-Yi& Lin, Yi-Wen& Wang, Shu-Huei…[et al.]. Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-504994

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-504994