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Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor κB Is a Steady Feature of Urinary Bladder Carcinogenesis
Joint Authors
Sotiropoulou-Bonikou, Georgia
Kominea, Athina
Balampani, Eleni
Kontos, Stylianos
Melachrinou, Maria
Bonikos, Dionysis
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The inescapable relationship between chronic inflammation and carcinogenesis has long been established.
Our objective was to investigate COX-2 and NF-κB immunohistochemical expression in a large series of normal epithelium and bladder carcinomas.
Methods.
Immunohistochemical methodology was performed on formalin-fixed, paraffin-embedded sections from urinary bladder carcinomas of 140 patients (94 males and 46 females with bladder carcinomas).
Results.
COX-2 expression is increased in the cytoplasm of bladder cells, during loss of cell differentiation (rs=0.61, P-value<.001) and in muscle invasive carcinomas (P-value<.001).
A strong positive association between tumor grade and nuclear expression of NFκB has been established.
A positive correlation between COX-2 and nuclear NFκB immunoreactivity was observed.
Conclusions.
The possible coordinated upregulation of NFκB and COX-2, during bladder carcinogenesis, indicates that agents inhibitors of these two molecules may represent a possible new treatment strategy, by virtue of their role in bladder carcinogenesis.
American Psychological Association (APA)
Kontos, Stylianos& Sotiropoulou-Bonikou, Georgia& Kominea, Athina& Melachrinou, Maria& Balampani, Eleni& Bonikos, Dionysis. 2010. Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor κB Is a Steady Feature of Urinary Bladder Carcinogenesis. Advances in Urology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-505005
Modern Language Association (MLA)
Kontos, Stylianos…[et al.]. Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor κB Is a Steady Feature of Urinary Bladder Carcinogenesis. Advances in Urology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-505005
American Medical Association (AMA)
Kontos, Stylianos& Sotiropoulou-Bonikou, Georgia& Kominea, Athina& Melachrinou, Maria& Balampani, Eleni& Bonikos, Dionysis. Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor κB Is a Steady Feature of Urinary Bladder Carcinogenesis. Advances in Urology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-505005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505005